![]() Four valves regulate blood flow through the heart: These chambers are enclosed in a protective sac called the pericardium. The upper two chambers are called the left atrium and right atrium, and the lower two are called the left and right ventricles. What is the structure (anatomy) of the heart? However, in some patients, lupus can also lead to heart conditions, some of which can be life-threatening. Commonly affected organs in lupus patients are skin, joints, kidneys and blood cells. In a person with lupus, persistent lupus-specific autoantibodies (antibodies that attack healthy proteins your body forms naturally) that are present in the blood cause organ inflammation and damage. Systemic lupus erythematosus (SLE or lupus) is a chronic, inflammatory autoimmune disease.
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